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It turned out that the supplement, the lotion, as well as the treatment with both products, not only lead to a reduction in hair loss but also to an increased anagen to telogen hair ratio, whereas no such effects could be measured for the control group

In experimental colitis models, ERS inhibitors such as sodium phenylbutyrate can significantly improve intestinal inflammation, indicating the important role of the ER stress PERK axis in IBD (101)

Cytosolic mtDNA activates the cGAS-STING axis, driving type I interferon responses and pro-inflammatory cytokine production, whereas extracellular or endolysosomal mtDNA stimulates toll-like receptor 9 (TLR9), leading to NF-B dependent inflammatory transcriptional programs

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