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Quantification of the volume of BBB disruption indicated by the T1 weighted, gadoliniumenhanced images revealed no significant differences between the untreated TBI group and the Immunocal-pretreated TBI group (Figure 1C)

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However, under normal conditions, this pathway is likely to be less significant, only becoming important when MHbR activity is disrupted (58)

17 Early identification through a careful assessment and history in patients at risk for opioid tolerance is essential for adequate pain-management planning

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