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Interestingly comparison of human OPCs (hOPCs) transplanted into young adult mice and aged mice showed that both wildtype and modified Neuropilin-1 (NRP1) knock out hOPCs migrated equal distances regardless of the age of the host, suggesting that in this context, the intrinsic properties of the transplanted cells can offset the aging environment (Wagstaff et al., 2024)

However, some orally-administered drugs are able to avoid first-pass metabolism , to some degree at least, as a result of lymphatic drug absorption

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