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Thiazolidinediones therefore promote increased FA uptake and storage in subcutaneous adipose tissue, reducing levels of circulating FA and triglycerides.79 Thiazolidinediones have also been shown to stimulate specific proteins involved in glucose metabolism, including pyruvate dehydrogenase.2 Overall, by reducing FA delivery to the heart and increasing flux through glycolysis, thiazolidinediones may help to rebalance the metabolic alterations in the diabetic heart

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The Foundation FAPESP did not influence in the design of the study and collection, analysis, and interpretation of data or the writing of the manuscript