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From the perspective of the unenthusiastic population health developments worldwide, as well as the COVID-19 crisis recently passed, the public health community urgently needs advice-focused, hands-on actions along with the drivers of those generating increasing social, health, and care inequalities

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In humans, two enzymatic reactions are dependent on vitamin B 12 methylmalonyl coenzyme A mutase (MUT) reaction and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) reaction (Fig 2)