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Inherited GSTM1 and NAT2 defects as concurrent risk modifiers in asbestos-related human malignant mesothelioma

Interestingly, many patients who relapse on tamoxifen therapy will respond to different types of hormonal manipulation including either ER downregulators/ER angatonists or aromatase inhibitors (AIs), implying that ER continues to play a major role in breast cancer progression (Pike et al ., 1993

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"These drugs are thought to work by engaging part of the brain called the hypothalamus, which helps regulate a wide variety of hormones," says Jena Shaw Tronieri, Senior Research Investigator at Penn's Center for Weight and Eating Disorders and a co-author of the study