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10.2%) and a high mortality of 39.5% during follow-up

For example, the silent information regulator 1 (SIRT1), a NAD + -dependent protein deacetylase, functions as a key upstream regulator for LKB1/AMPK signaling in the liver 50

[DOI] [PMC free article] [PubMed] [Google Scholar] 597.Li RL, Fan CH, Gong SY, Kang S

Acknowledgements We would like to thank Instituto do Osso e da Cartilagem for the support and Jos Fbio Lana for his remarkable academic contributions towards the production of this manuscript

Conversely in chronic rhinosinusitis SIRT5 enhances glutamine metabolism to facilitate M2 polarization worsening edema (74)