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In conclusion, curcumin exerts significant antidepressant effects through multitarget actions, including modulation of the hypothalamic-pituitary-adrenal axis, attenuation of inflammatory responses, restoration of synaptic plasticity, and normalization of neural circuit function, positioning it as a promising natural antidepressant candidate for addressing the complex pathophysiology of major depressive disorder

However, these models struggle with capturing long-range dependencies in text [82]

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infantis and XOS) were administered to C57BL/6 mice for 21 days

Research models evaluate these pathways by administering precise g doses of B12 and observing biochemical or physiological markers