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The data were processed using the program XDS 42 and the structures were solved by molecular replacement using the program PHASER 43 with the structure of tynorphin bound hDPP III (1726) as search model

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2.6 Meta-analysis Meta-analysis was performed using the R statistical program, R version 4.4.2 (The R Foundation for Statistical Computing, Wirtschaftsuniversitt Wien, Vienna, Austria) (Sterne et al., 2016