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Administration of CMI has been reported to increase the plasma levels of phenobarbital, if given concomitantly ( seeCLINICAL PHARMACOLOGY, Interactions)
The translational relevance of these finding is demonstrated in retrospective studies examining genomic differences in tumors responsive and resistant to treatment
( 20:1103 ) Li S, Yang C, Wang W et al (2024) First-in-human study to assess the safety, tolerability, and pharmacokinetics of intravenous SHPL-49 following single- and multiple-ascending-dose administration in healthy adults
10.1038/cddis.2013.387 89 VitalA.VitalC.LagueneyA.FerrerX.Ribire-BachelierC.LatourP.et al
Substitutes of Key B12 PFS 1500 mcg Injection 1 ml may vary in color, size, or shape due to differences in manufacturing and branding, but this does not affect how they work
