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Typical daily range: 2.55 mg per day 2.5 mg/day to start, increasing to 5 mg/day, or split as 2.5 mg twice daily

These effects could potentially mitigate age-related cardiac decline and support overall heart health, though further studies are needed to confirm these benefits in humans

Furthermore, vitamin B12 is important for brain health, as it helps in the production of neurotransmitters that regulate mood and cognitive functions

In preclinical heart failure models, NNMT enzyme inhibition markedly reduced cardiac 1-MNA (by 77.1%), improved cardiac function, reduced left ventricular hypertrophy and fibrosis, and decreased pro-inflammatory gene expression

doi:10.1053/jvet.2003.50058 Kang YA, Choi HR, Na JI, et al