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Abstract T cellbased immunotherapies have transformed cancer treatment, yet their efficacy in solid tumors is constrained by the nutrient-poor and oxidative tumor microenvironment (TME)

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This study, where 2586 patients were treated with either rofecoxib or placebo, inferred that long term use of rofecoxib is associated with twice the risk of heart attack or stroke versus placebo [118], [119]