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In 2024, the investigation of new antidiabetic therapies and metformin was reported on asthma exacerbations in people with asthma and type 2 diabetes

The latter in response to stimulation by intestinal microbial antigens, particularly LPS, upregulate the production of proinflammatory cytokines (e.g., IL-1, IL-6, TNF) and reactive oxygen species (ROS), contributing to the enhancement of pro-inflammatory reactions (Van Spaendonk et al., 2017)

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Melatonin upregulates the pyruvate dehydrogenase complex (PDC), reprogramming pyruvate in mitochondria, promoting the metabolism of pyruvate to acetyl-CoA in mitochondria, and inhibiting the Warburg effect (Reiter et al., 2020)