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11, 12, 13, 14, 15 Direct and indirect studies have demonstrated that oxidative stress from reactive oxygen species (ROS) generated through mitochondria, xanthine oxidase, and the NADPH oxidase system 16, 17, 18, 19, 20, 21 is one of the important factors in the pathogenesis of myocardial ischemia

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PMID: 167 HiguchiBSRodriguesNGonzagaMICicogna PaioloJCStefanuttoNOmoriWPet al

5C), from three pharmacophoric groups: hydrophobic, hydrogen bond donors and acceptors

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