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In these cases, L-carnitine supplements may help reduce symptoms such as fatigue and weakness

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In contrast, studies using the Surf1-KO mice (a model of early-onset partial COX-deficiency) and the COX15 / mice showed no change in COX-activity, percentage COX-deficient fibers, and, importantly, no induction of mitochondrial biogenesis

doi: 10.1212/WNL.0000000000002307 72 MarogianniCSokratousMDardiotisEHadjigeorgiouGMBogdanosDXiromerisiouG

FEBS Lett 18:3337 [DOI] [PubMed] [Google Scholar] Weber P, Bendich A, Schalch W (1996) Vitamin C and human health-a review of recent data relevant to human requirements
