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Importantly, it may take two weeks or longer to achieve this extent of accumulation at constant dosing because of the relatively long elimination half-lives of CMI and DMI ( seeDOSAGE AND ADMINISTRATION)

Furthermore, mice that were administered with milk-derived exosomes showed reduced signs of inflammation induced by DSS, which was accompanied by a lower expression of IL-6 and TNF-, suggesting a protective effect in the context of colitis (240)

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