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The apyrimidinic endonuclease/redox effector factor (APE1) is an important enzyme for DNA-damaged base removal, and decreased APE1 levels in sensory neurons increase neurotoxicity in OIPN models, targeting APE1 by the small molecules APX3330 and APX2009
10.1016/j.bbrep.2023.101578 173
NAC is a precursor to the amino acid cysteine, which ultimately plays two key metabolic roles
Synthesis of serine by the dog kidney in vivo
Schmitt, B., Vicenzi, M., Garrel, C., & Denis, F
