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In line with this, lung samples had even more distinct patterns, reflecting differences between clones from bronchial epithelium and bulk lung tissue (also containing alveolar epithelium and immune cells amongst other cells) 43

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The cytotoxicity of As 2 O 3 occurred through the generation of reactive oxygen species (ROS), thus inhibiting radical scavenging systems would enhance the therapeutic efficacy of As 2 O 3 provided that normal cells were relatively resistant to such a measure