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Authors' contributions Participated in research design: Ghayour, Abdolmaleki, Conducted experiments: Ghayour, Abdolmaleki, Behnam, Performed data analysis: Ghayour, Abdolmaleki, Wrote or contributed to the writing of the manuscript: Ghayour, Abdolmaleki, Behnam

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All statistical analyses were conducted using the TwoSampleMR (for extracting genetic associations where publicly available and harmonization), MendelianRandomization and MRPRESSO (for deriving MR estimates), and meta package (for assessing heterogeneity in sex differences) in R (version 4.0.1, R Foundation for Statistical Computing, Vienna, Austria)