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Exogenous administration of CNTF significantly extends the survival of spinal motor neurons in rats 44,45 , prevents retrograde degeneration of anterior thalamic neurons 46

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By inhibiting NNMT, 5-Amino-1MQ may spare nicotinamide for NAD+ synthesis via the salvage pathway, thereby activating SIRT1 (Sirtuin 1) pathways associated with mitochondrial biogenesis, fat oxidation, and metabolic flexibility [3]