female network iv glutathione thread 23 Nutritional priorities to support GLP-1 therapy for obesity: a joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society Single-cell mapping of regulatory DNA-protein

In a randomized controlled trial of 72 patients with type 2 diabetes and reduced heart rate variability, oral supplementation with 800 mg/day of lipoic acid for four months resulted in significant improvement in two out of four measures of heart rate variability compared to placebo (81)

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78% were White, 16% were Asian, 2.9% were Hispanic or Latino, 2.1% were Black or African American, and 80 mL/min)

Homocysteine can also be high with folate deficiency so folate should also be measured to rule that out

Another biomarker that may be clinically useful is serum -glutamyltransferase (GGT) which is primarily involved in the metabolism of extracellular reduced glutathione and when elevated (above 9 U/L in women and above 1420 U/L in men) but still within normal reference ranges may indicate glutathione depletion and be associated with chronic disease risk [33]