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In addition, our preliminary study showed that maternal diabetes induces significantly decreased expression of SOD2 and ER in brain, resulting in more severe ALBs in male offspring compared to female offspring since male offspring have relatively much lower basal ER expression in brain, making male offspring more susceptible to hyperglycemia-induced damage

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This condition occurs when the arteries in the lungs become narrowed and stiff, forcing the right side of the heart to work harder