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One of the functions of CHL1 is to regulate neuronal survival and growth and induce dendritic spine pruning in developing pyramidal neurons together with Semaphorin 3B

In this section, we review different classes of treatment agents undergoing clinical trials (Table 2), including vitamins [229, 230], FGF21 agonist antibodies or analogs [231, 232], diets [233], combined metabolic activators (CMAs) [234], anti-T2DM drugs [235], PPAR agonist [236], regulation of lipogenesis [237], bacterial alteration [238], hormone therapy [239], and C-C chemokine receptors antagonist [240]

IACUC approval was provided by the Institutional Animal Care and Use Committee of Joint Service Support Force 940 Hospital of PLA (number 2021LQBZ015)

Several findings demonstrate that L-carnitine treatment inhibits the MDA production and reverses the depletion of GSH as well as erythrocyte antioxidant enzyme activities in CRF animals [42]

In general, many researchers believe PQQ is safe