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Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism

doi: 10.3389/fmicb.2025.1677102 Received 31 July 2025 Accepted 31 October 2025 Published 21 November 2025 Volume 16 - 2025 Edited by Gregg Pettis, Louisiana State University, United States Reviewed by Jong Hyun Ham, Louisiana State University, United States Cong Zhang, Qingdao Agricultural University, China Updates Copyright 2025 Shigeta, Shiraishi, Schroll, Lauer, Keppler, Sakai and Yurimoto

Nanocarriers for brain targeting were designed not only in the 100200 nm but also in the larger, 300500 nm size ranges [62]

Bone Health The vitamin D2 in button mushrooms directly supports calcium absorption and bone mineralization

GHK-Cu is also shown to stimulate collagen and elastin, smoothing and firming the skin over time without the potential skin irritation of prescription tretinoin or over-the-counter retinol