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doi: 10.3389/fnut.2018.00011

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The progressive drying and keratinization of the conjunctiva, particularly on the nasal and temporal conjunctiva, results in the development of irregularly shaped spots termed Bitot (bee toe) spots after the French physician, Pierre Bitot, who first described them

The process is observed either under massive increase of radical species or under physiological ROS flux

Fessel J
