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The Psychobiotic Approach: Healing Beyond the Gut Probiotics, prebiotics, and synbiotics can help restore gut balance and modulate the gut-brain axis
51,52,81 However, this evidence is still speculative and is merely hypothesis-generating to a large extent and needs to be confirmed by well-designed multi-center randomized clinical trials, including prospective and standardized analysis of the flora

Furthermore, the combined therapy was associated with better treatment adherence

Eligible study designs included RCTs, open-label studies, non-randomized studies, and observational studies

doi: 10.7554/eLife.50631CrossRefGoogle ScholarPubMed Chiu, K
