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It is when the mutation load exceeds this threshold, we see metabolic dysfunction and clinical symptoms associated with a disease state (Niyazov et al., 2016)
Wordinger, The role of steroids in outflow resistance
Blood 99(1):326-35, 2002

Phase II enzymes may be either microsomal or cytosolic
Effects of folic acid before and after vitamin B12 on plasma homocysteine concentrations in hemodialysis patients with known MTHFR genotypes