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Rahman et al, 1996
FIGURE 2 Table 1 Insulin-like growth factor-1 signaling pathway-targeting miRNAs
The pathogenesis involves a type IV hypersensitivity reaction where the drug acts as a hapten, binding to tubular cells and inducing a T-cell-mediated immune response
10.3389/fonc.2021.759346 68 LuoY.HuangQ.HeB.LiuY.HuangS.XiaoJ
The proposed mechanistic model is that elevated Ang II reduces ATP content in skeletal muscle, which is supposed to activate AMPK, while Ang II inhibits AMPK activation, causing severe ATP depletion and muscle atrophy
