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This would approach cytoprotective capabilities, where stomach epithelium/endothelium protection might be easily achieved and further extended to the general level (protection of other organs) (cytoprotection to organoprotection) [24]

In vitro studies have demonstrated that RCC cells exhibit high expression of both IGF-1 and IGFBP-3, which have opposing effects: inhibition of IGF-1 reduces RCC cell proliferation, while blocking IGFBP-3 increases it.39 This response occurs because IGF-1 signals through IGF1R triggering proliferative effects and promoting IGFBP-3 expression, the latter modulating the IGF-1 actions

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