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This condition, combined with continued exposure to stressors and vulnerability, may predispose it to alter the immune system with the simultaneous release of pro-inflammatory cytokines, which in turn may activate the production of reactive oxidative species and, together, may eventually reach the brain and promote a neuro-inflammatory state [127,128]

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Our findings show that e-cigarette use adversely affects the pharmacokinetics of inhaled therapies, reducing efficacy through impaired drug distribution, clearance and absorption, as well as alterations in metabolism