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Description
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The majority of current pharmacological therapies are targeted at lowering neural excitability and thereby avoiding seizures

Potential mechanisms range from changes in the extracellular matrix (myocardial fibrosis, inflammation) 79 to impaired calcium handling 80 or modification of sarcomeric proteins, 81 which have all been reviewed by others

Belardinelli R, Mucaj A, Lacalaprice F, Solenghi M, Principi F, Tiano L, Littarru GP

10.1038/srep26745 116 RathS.HeidrichB.PieperD
