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In contrast, for SARS-COV-1, WRAIR-5001 displayed modest affinity (K D = 3.45 nM), with strong neutralization (IC 50 = 0.22 g/ml, Fig

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These findings further elucidate the potential role of oxidative stress, as well as GSH depletion, as driving mechanisms in the development of the cyclosporine-induced cholestasis (Moran et al., 1998

3.1.2 Effect of sitagliptin on the mRNA expression of BAX, BCL2 and p53 in HepG2 cells Figure 2 illustrates a significant reduction in BCL2 expression level was reported upon treatment of HepG2 cells with the standard anticancer drug doxorubicin in a concentration of 200 mole or with sitagliptin (IC50: 89 M