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Humans express four different PKA regulatory subunit genes, PRKAR1A (protein kinase cAMP-dependent type I regulatory subunit alpha), PRKAR1B (protein kinase cAMP-dependent type I regulatory subunit beta), PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha), and PRKAR2B (protein kinase cAMP-dependent type II regulatory subunit beta)

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Changes in the biochemical composition of the IVD result in impaired swelling within the disc, consequently, affecting the exchange of nutrients and waste products

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