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Importantly, PCs can synthesize precursors of inflammation-inducing substances 53 that are released and subsequently produce modulatory oxidative metabolites implicated in the pathogenesis of ARDS

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GSH availability is tightly controlled though transcriptional, post-transcriptional, and post-translational mechanisms

Therapies targeting the RAS activation pathway or RAS effector pathway can be combined with direct RAS inhibitors, immune checkpoint inhibitors, or T cell-targeting approaches to treat RAS-mutant tumors

Indeed, they observed that oral administration of RA (25-200 mg/kg) reduced macroscopic lesions, ulcerative area, intestinal weight/length ratio, and diarrheal index