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Stage 1: Follicular phase = increasing estrogen Estradiol is mainly produced in the ovaries
There's no published research showing any sort of negative interactions between the two

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[DOI] [PMC free article] [PubMed] [Google Scholar] 124.Liu T, Sun W, Guo S, Chen T, Zhu M, Yuan Z, Li B, Lu J, Shao Y, Qu Y, et al

Oxidative Stress in Cognitive and Epigenetic Aging: A Retrospective Glance
