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While homozygotes of an Alox15 variant that almost completely ablates 15-LOX activity tended to have a reduced risk for coronary artery disease, heterozygotes paradoxically have increased risk of disease (292)
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Melena strongly suggests, and hematemesis confirms, that bleeding is of upper gastrointestinal originPeptic ulcer, the most common cause of gastrointestinal hemorrhage, should be pursued through questions about epigastric distress, the relationship of symptoms to food intake, and a history of peptic ulcer disease
