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CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation

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Although synthesized in the cytosol by the consecutive actions of -glutamate-cysteine ligase (GCL) and glutathione synthetase (GS), glutathione is also present in the ER, which contains a small but functionally significant fraction of the total cellular pool 9

( (2) Proposed eCQM Adoptions As we stated in the FY 2018 IPPS/LTCH PPS final rule (82 FR 38479), we intend to continue to align the eCQM reporting requirements for the Medicare Promoting Interoperability Program with similar requirements under the Hospital IQR Program to the extent feasible