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PubMed , PLoS ONE , vol

Peng, R

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Collagen, a protein that naturally occurs in the body, plays a crucial role in maintaining skin elasticity and hydration

Users stopping retinoids frequently report rapid regression of benefits within 4-8 weeks including increased breakouts sometimes exceeding pre-treatment levels (retinoid rebound), accelerated fine line reappearance approaching or surpassing baseline, skin texture deterioration returning to pre-treatment roughness, and psychological dependency from dramatic visible decline creating pressure for continuous use despite side effect burden