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The predominant oxylipins include AA derivatives like prostaglandins, thromboxanes, and leukotrienes ( Specialized pro-resolving mediators (SPMs) are a class of PUFA-derived lipid mediators ( Astrocytes, which hold about 1012% of the brains DHA, alongside oligodendrocytes and microglia, which account for 5% and 2%, respectively ( 5.2 Mitochondrial stability and antioxidant effects Although the effects of omega-3 PUFAs on ROS production within mitochondria have yielded mixed results, omega-3 PUFAs are known to influence mitochondrial function in several ways, including impacts on membrane potential, respiration rates, the activity of mitochondrial complexes, and ROS production

Furthermore, by examining the lipid composition, we can quantify the abundance and type of fatty acids, especially omega-3 such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are essential for terrestrial animals, including birds, bats, and riparian spiders

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Activation of CB1R by THC disrupts the balance between excitatory and inhibitory neurotransmission, particularly affecting GABAergic and glutamatergic systems (Castelli et al., 2023a