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[15] Compound I + HS Compound II + S [2] Compound II + HS APX + S + H 2 O [3] In ascorbate peroxidase, Compound I is a transient (green) species and contains a high-valent iron species (known as ferryl heme, Fe IV ) and a porphyrin pi-cation radical, [16] [17] as found in horseradish peroxidase

Apply twice to thrice a week

These tools can also introduce proximal off-target edits within the mitochondrial genome itself, and certain deaminase variants retain residual RNA-editing activity, further exacerbating unintended molecular perturbations [546, 550, 552]

doi: 10.1038/s41419-017-0200-7, 242

Table 1 Key molecular players in ferroptosis and TAM interactions