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FIGURE 8 3.3 Urinary system diseases Plasma levels of TMAO have been found to have a clear association with various human urinary system diseases and serve as a key biomarker for several kidney diseases ( 3.3.1 Chronic kidney disease (CKD) Metabolomic analysis shows that chronic kidney disease (CKD) patients have higher plasma TMAO concentrations (Prokopienko et al., 2019)