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This is why the Phase 1 clinical trial chose prostate cancer patients

By delivering methylcobalamin or cyanocobalamin directly into muscle tissue, the vitamin enters your bloodstream immediately at nearly 100% bioavailability
The ratio of Firmicutes to Bacteroidetes is a commonly-studied change with an increase often linked to HFD consumption/obesity in mice 43,44 and humans 45,46 (for review, see John and Mullin, 2016 47 )

This is especially true for those that are vegan or have had gastric bypass surgery, since they do not absorb enough B12 to keep your stores well-stocked

Some people may experience headaches or digestive discomfort, but these side effects usually resolve quickly