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The fact that specific regions of the nervous system exhibit differential vulnerabilities to aging and various neurodegenerative diseases is a reflection of both the specificity in the aetiology of each disease and of the heterogeneity in neuronal (and non-neuronal) responses to cell-damaging processes associated with each of the diseases [3]

473,474 AMPK activate peroxisome proliferator-activated receptor coactivator-1 (PGC-1), the key factor in mitochondrial biogenesis, thus enhancing mitochondrial respiratory and metabolic functions

In erythrocyte, plasma, whole-blood, PBMC, splenocyte, or other blood-derived systems, peptide purity, residual TFA or other counter-ions, pH, osmolarity, residual solvents, endotoxin, aggregation, storage history, and freeze-thaw exposure can affect the readout