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Such structural modifications increase the selectivity and potency of these compounds, presenting new potential directions and applications for cancer therapy [1073,1074,1075,1076,1077]

Alternatively, supplementing the diet with a ketone ester has proven effective in lessening A and tau pathologies and improving cognitive function in mouse models of AD (Cheng et al

Rhrig 63 (24), 7847-7859 A covalent inhibitor targeting Cys-349 of LIMK1 confers selectivity over LIMK2 Jon B

Front Neurosci 13:859

106 Similarly, a dose of 1,000 mg/kg body weight was found to be safe in Swiss albino mice administered with 250, 500, 750, or 1,000 mg/kg body weight of 50% hydroethanolic Jamun seed extract as none of these doses could alter the behavior or induce mortality in mice in acute toxicity studies