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The 0.01 mg/kg dose that showed consistent effects in rats translates to approximately 0.0016 to 0.004 mg/kg in humans, which works out to roughly 0.112 to 0.28 mg for a 154-pound person

Similar content being viewed by others Introduction Despite the number of pharmacologic agents on the market for the treatment of depression, novel antidepressants with efficacy and tolerability are still in much need

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However, prolonged exposure to catecholamines not only increases the workload on a failing heart but also results in impaired AR responses, due to increased 1 -AR desensitization and downregulation (Lymperopoulos et al., 2013

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