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Therefore, the problem that the agents successful in pre-clinical experimental autoimmune encephalitis trials, were either less effective in patients, worsened disease or caused unexpected, severe adverse events (60), may be at least partly solved with the more suited cuprizone model that reflects a toxic experimental model (12)
The metabolism of peptides and proteins usually starts from the action of endopeptidase and then undergoes multi-step enzymatic degradation to produce the final metabolite amino acids, which enter the amino acid pool in vivo ( 3 H]BPC157, and their structures were predicted by LC-MS/MS molecular weight identification and comparison with standards
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