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The epidemiological data presented in Table 1 sheds light on the prevalence of DPN and painful DPN, and the percentage of undiagnosed DPN and painful DPN among these patients [5, 8, 24,25,26,27,28,29,30,31,32]

Further investigation is required to examine the role that metabolism-dependent genetic mechanisms play in the development of depression and whether these mechanisms can have effects similar to those of antidepressants

Because the two mechanisms operate through independent molecular pathways

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Additionally, it lowers the liver index, total cholesterol, leptin level, and triglyceride (TG) [132]