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Critically, these effects were achieved without food intake suppression, distinguishing MOTS-c from GLP-1 receptor agonists whose primary mechanism involves appetite reduction

482 A Phase II clinical trial (NCT04669808) for the in situ treatment of basal cell carcinoma showed a positive therapeutic effect and achieved 100% complete clearance

Centrifuge at 8,000 g for 10 min at 4C 4

Additional comparison was made with targeted protein measurements of serum samples from age- and sex-matched autoantibody-negative unaffected family members (UFMs, n =194)