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Types of Variables color: Light brown to black (may have color variegation) May have pink/white areas indicating inflammation Inflammation Inflammation is a complex set of responses to infection and injury involving leukocytes as the principal cellular mediators in the bodys defense against pathogenic organisms

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After positive results from the Veterans Affairs HDL-C Intervention trial (VA-HIT) trial, showing a 22% reduction in ASCVD with gemfibrozil (1,200 mg/day) in the 1990s [8], major fibrate trials, including the Lower Extremity Arterial Disease Event Reduction (LEADER) [5], Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) [6], and Action to Control Cardiovascular Risk in Diabetes (ACCORD)-Lipid [7] in the 2000s, failed to demonstrate ASCVD prevention with fibrates

[4] Emerging histopathologic markers: Cellular remnants of melanocytes (CRMs) Large CRMs within the nail plate have recently been recognised as a valuable diagnostic marker for distinguishing SUM from benign melanocytic proliferations such as nail matrix nevi (NMN)

Additionally, TMAO has been demonstrated to worsen reduced glucose tolerance, limit hepatic insulin signaling, and incite inflammation in adipose tissue in vivoall essential elements of the atherosclerotic pathway [76]