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These medications have reshaped how clinicians think about metabolic health, addressing not only body weight but also fatty liver, insulin resistance, and cardiovascular risk

Early studies in the late 1990s, suggested that high circulating IGF1 concentrations are associated with an increasing risk of colorectal cancer 23, 73

p53 inhibits ferroptosis by reducing the accumulation of toxic lipid ROS and inducing the expression of cyclin-dependent kinase inhibitor 1A (CDKN1A/p21) (Figure 1) (Li and Li, 2020

2.15 High-speed atomic force microscopy (AFM) Atomic force microscopy (AFM) is a very-high-resolution imaging technique (in some instances, it can have a resolution on the order of fractions of a nanometer) based on using a mechanical probe consisting of a cantilever and a sharp tip, which can be modified in many ways to investigate surface properties, to gather information by sensing, feeling, or touching the surface of a sample

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